MYC copy gain, chromosomal instability and PI3K activation as potential markers of unfavourable outcome in trastuzumab-treated patients with metastatic breast cancer

BACKGROUND: There is an unmet need for more efficient patient stratification for receiving trastuzumab in the metastatic breast cancer (mBC) setting, since only part of such patients benefit from the addition of this agent to chemotherapy. The aim of this study was to investigate the prognostic valu...

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Detaylı Bibliyografya
Yayımlandı:J Transl Med
Asıl Yazarlar: Gogas, Helen, Kotoula, Vassiliki, Alexopoulou, Zoi, Christodoulou, Christos, Kostopoulos, Ioannis, Bobos, Mattheos, Raptou, Georgia, Charalambous, Elpida, Tsolaki, Eleftheria, Xanthakis, Ioannis, Pentheroudakis, George, Koutras, Angelos, Bafaloukos, Dimitrios, Papakostas, Pavlos, Aravantinos, Gerasimos, Psyrri, Amanda, Petraki, Kalliopi, Kalogeras, Konstantine T., Pectasides, Dimitrios, Fountzilas, George
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2016
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869295/
https://ncbi.nlm.nih.gov/pubmed/27184134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0883-z
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