MYC copy gain, chromosomal instability and PI3K activation as potential markers of unfavourable outcome in trastuzumab-treated patients with metastatic breast cancer

BACKGROUND: There is an unmet need for more efficient patient stratification for receiving trastuzumab in the metastatic breast cancer (mBC) setting, since only part of such patients benefit from the addition of this agent to chemotherapy. The aim of this study was to investigate the prognostic valu...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Gogas, Helen, Kotoula, Vassiliki, Alexopoulou, Zoi, Christodoulou, Christos, Kostopoulos, Ioannis, Bobos, Mattheos, Raptou, Georgia, Charalambous, Elpida, Tsolaki, Eleftheria, Xanthakis, Ioannis, Pentheroudakis, George, Koutras, Angelos, Bafaloukos, Dimitrios, Papakostas, Pavlos, Aravantinos, Gerasimos, Psyrri, Amanda, Petraki, Kalliopi, Kalogeras, Konstantine T., Pectasides, Dimitrios, Fountzilas, George
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869295/
https://ncbi.nlm.nih.gov/pubmed/27184134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0883-z
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