MYC copy gain, chromosomal instability and PI3K activation as potential markers of unfavourable outcome in trastuzumab-treated patients with metastatic breast cancer

BACKGROUND: There is an unmet need for more efficient patient stratification for receiving trastuzumab in the metastatic breast cancer (mBC) setting, since only part of such patients benefit from the addition of this agent to chemotherapy. The aim of this study was to investigate the prognostic valu...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Gogas, Helen, Kotoula, Vassiliki, Alexopoulou, Zoi, Christodoulou, Christos, Kostopoulos, Ioannis, Bobos, Mattheos, Raptou, Georgia, Charalambous, Elpida, Tsolaki, Eleftheria, Xanthakis, Ioannis, Pentheroudakis, George, Koutras, Angelos, Bafaloukos, Dimitrios, Papakostas, Pavlos, Aravantinos, Gerasimos, Psyrri, Amanda, Petraki, Kalliopi, Kalogeras, Konstantine T., Pectasides, Dimitrios, Fountzilas, George
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869295/
https://ncbi.nlm.nih.gov/pubmed/27184134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0883-z
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