MYC copy gain, chromosomal instability and PI3K activation as potential markers of unfavourable outcome in trastuzumab-treated patients with metastatic breast cancer

BACKGROUND: There is an unmet need for more efficient patient stratification for receiving trastuzumab in the metastatic breast cancer (mBC) setting, since only part of such patients benefit from the addition of this agent to chemotherapy. The aim of this study was to investigate the prognostic valu...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Gogas, Helen, Kotoula, Vassiliki, Alexopoulou, Zoi, Christodoulou, Christos, Kostopoulos, Ioannis, Bobos, Mattheos, Raptou, Georgia, Charalambous, Elpida, Tsolaki, Eleftheria, Xanthakis, Ioannis, Pentheroudakis, George, Koutras, Angelos, Bafaloukos, Dimitrios, Papakostas, Pavlos, Aravantinos, Gerasimos, Psyrri, Amanda, Petraki, Kalliopi, Kalogeras, Konstantine T., Pectasides, Dimitrios, Fountzilas, George
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869295/
https://ncbi.nlm.nih.gov/pubmed/27184134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0883-z
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