The effect of growth rate on pyrazinamide activity in Mycobacterium tuberculosis - insights for early bactericidal activity?

BACKGROUND: Pyrazinamide (PZA) plays an essential part in the shortened six-month tuberculosis (TB) treatment course due to its activity against slow-growing and non-replicating organisms. We tested whether PZA preferentially targets slow growing cells of Mycobacterium tuberculosis that could be rep...

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Veröffentlicht in:BMC Infect Dis
Hauptverfasser: Pullan, Steven T., Allnutt, Jon C., Devine, Rebecca, Hatch, Kim A., Jeeves, Rose E., Hendon-Dunn, Charlotte L., Marsh, Philip D., Bacon, Joanna
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869200/
https://ncbi.nlm.nih.gov/pubmed/27184366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12879-016-1533-z
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