A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies

Nociceptin/Orphanin FQ (N/OFQ) is an endogenous ligand of the N/OFQ peptide (NOP) receptor, which is a G protein-coupled receptor in brain regions associated with mood disorders. We used a novel, potent, and selective orally bioavailable antagonist, LY2940094, to test the hypothesis that blockade of...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Post, Anke, Smart, Trevor S, Krikke-Workel, Judith, Dawson, Gerard R, Harmer, Catherine J, Browning, Michael, Jackson, Kimberley, Kakar, Rishi, Mohs, Richard, Statnick, Michael, Wafford, Keith, McCarthy, Andrew, Barth, Vanessa, Witkin, Jeffrey M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869049/
https://ncbi.nlm.nih.gov/pubmed/26585287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.348
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