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XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence

X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is well known as an antagonist of XIAP-mediated caspase inhibition. Although XAF1 serves as a tumor-suppressor gene, the role of XAF1 in cellular senescence remains unclear. We found that XAF1 expression was increased by genotoxic age...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Heo, Jong-Ik, Kim, Wonwoo, Choi, Kyu Jin, Bae, Sangwoo, Jeong, Jae-Hoon, Kim, Kwang Seok
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868675/
https://ncbi.nlm.nih.gov/pubmed/26802028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6962
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