Enhanced glucose transport, but not phosphorylation capacity, ameliorates lipopolysaccharide-induced impairments in insulin stimulated-muscle glucose uptake

Lipopolysaccharide (LPS) is known to impair insulin stimulated muscle glucose uptake. We determined if increased glucose transport (GLUT4) or phosphorylation capacity (hexokinase II; HKII) could overcome the impairment in muscle glucose uptake (MGU). We utilized mice that over-expressed GLUT4 (GLUT4...

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Udgivet i:Shock
Main Authors: Otero, Yolanda F., Mulligan, Kimberly X., Barnes, Tammy M., Ford, Eric A., Malabanan, Carlo M., Zong, Haihong, Pessin, Jeffrey E., Wasserman, David H., Guinness, Owen P.M
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868638/
https://ncbi.nlm.nih.gov/pubmed/26682946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000550
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