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Extended survival of misfolded G85R SOD1-linked ALS mice by transgenic expression of chaperone Hsp110
Recent studies have indicated that mammalian cells contain a cytosolic protein disaggregation machinery comprised of Hsc70, DnaJ homologs, and Hsp110 proteins, the last of which acts to accelerate a rate-limiting step of nucleotide exchange of Hsc70. We tested the ability of transgenic overexpressio...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4868459/ https://ncbi.nlm.nih.gov/pubmed/27114530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604885113 |
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