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Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS
Recent studies suggest that superoxide dismutase 1 (SOD1)-linked amyotrophic lateral sclerosis results from destabilization and misfolding of mutant forms of this abundant cytosolic enzyme. Here, we have tracked the expression and fate of a misfolding-prone human SOD1, G85R, fused to YFP, in a line...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2631083/ https://ncbi.nlm.nih.gov/pubmed/19171884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813045106 |
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