Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS

Recent studies suggest that superoxide dismutase 1 (SOD1)-linked amyotrophic lateral sclerosis results from destabilization and misfolding of mutant forms of this abundant cytosolic enzyme. Here, we have tracked the expression and fate of a misfolding-prone human SOD1, G85R, fused to YFP, in a line...

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Bibliografiske detaljer
Main Authors: Wang, Jiou, Farr, George W., Zeiss, Caroline J., Rodriguez-Gil, Diego J., Wilson, Jean H., Furtak, Krystyna, Rutkowski, D. Thomas, Kaufman, Randal J., Ruse, Cristian I., Yates, John R., Perrin, Steve, Feany, Mel B., Horwich, Arthur L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631083/
https://ncbi.nlm.nih.gov/pubmed/19171884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813045106
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