Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18

Interleukin (IL)-18 is an important effector of innate and adaptive immunity, but its expression must also be tightly regulated because it can potentiate lethal systemic inflammation and death. Healthy and septic human neonates demonstrate elevated serum concentrations of IL-18 compared with adults....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wynn, James Lawrence, Wilson, Chris S., Hawiger, Jacek, Scumpia, Philip O., Marshall, Andrew F., Liu, Jin-Hua, Zharkikh, Irina, Wong, Hector R., Lahni, Patrick, Benjamin, John T., Plosa, Erin J., Weitkamp, Jörn-Hendrik, Sherwood, Edward R., Moldawer, Lyle L., Ungaro, Ricardo, Baker, Henry V., Lopez, M. Cecilia, McElroy, Steven J., Colliou, Natacha, Mohamadzadeh, Mansour, Moore, Daniel Jensen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868456/
https://ncbi.nlm.nih.gov/pubmed/27114524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515793113
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