Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18

Interleukin (IL)-18 is an important effector of innate and adaptive immunity, but its expression must also be tightly regulated because it can potentiate lethal systemic inflammation and death. Healthy and septic human neonates demonstrate elevated serum concentrations of IL-18 compared with adults....

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Wynn, James Lawrence, Wilson, Chris S., Hawiger, Jacek, Scumpia, Philip O., Marshall, Andrew F., Liu, Jin-Hua, Zharkikh, Irina, Wong, Hector R., Lahni, Patrick, Benjamin, John T., Plosa, Erin J., Weitkamp, Jörn-Hendrik, Sherwood, Edward R., Moldawer, Lyle L., Ungaro, Ricardo, Baker, Henry V., Lopez, M. Cecilia, McElroy, Steven J., Colliou, Natacha, Mohamadzadeh, Mansour, Moore, Daniel Jensen
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868456/
https://ncbi.nlm.nih.gov/pubmed/27114524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515793113
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