Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists

Neonates exhibit an increased risk of sepsis mortality compared with adults. We show that in contrast to adults, survival from polymicrobial sepsis in murine neonates does not depend on an intact adaptive immune system and is not improved by T cell–directed adaptive immunotherapy. Furthermore, neona...

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Detalhes bibliográficos
Main Authors: Wynn, James L., Scumpia, Philip O., Winfield, Robert D., Delano, Matthew J., Kelly-Scumpia, Kindra, Barker, Tolga, Ungaro, Ricardo, Levy, Ofer, Moldawer, Lyle L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518883/
https://ncbi.nlm.nih.gov/pubmed/18591384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-130500
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