Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists

Neonates exhibit an increased risk of sepsis mortality compared with adults. We show that in contrast to adults, survival from polymicrobial sepsis in murine neonates does not depend on an intact adaptive immune system and is not improved by T cell–directed adaptive immunotherapy. Furthermore, neona...

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Detaylı Bibliyografya
Asıl Yazarlar: Wynn, James L., Scumpia, Philip O., Winfield, Robert D., Delano, Matthew J., Kelly-Scumpia, Kindra, Barker, Tolga, Ungaro, Ricardo, Levy, Ofer, Moldawer, Lyle L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2008
Konular:
Immunobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518883/
https://ncbi.nlm.nih.gov/pubmed/18591384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-130500
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