Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis

Apoptosis of CD4(+) T cells and T(H)2 polarization are hallmarks of sepsis-induced immunoparalysis. In this study, we characterized sepsis-induced adaptive immune dysfunction and examined whether improving T-cell effector function can improve outcome to sepsis. We found that septic mice produced les...

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Main Authors: Scumpia, Philip O., Delano, Matthew J., Kelly-Scumpia, Kindra M., Weinstein, Jason S., Wynn, James L., Winfield, Robert D., Xia, Changqing, Chung, Chun Shiang, Ayala, Alfred, Atkinson, Mark A., Reeves, Westley H., Clare-Salzler, Michael J., Moldawer, Lyle L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2007
Fag:
Immunobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077315/
https://ncbi.nlm.nih.gov/pubmed/17690255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-087171
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