MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis

Polymicrobial sepsis alters the adaptive immune response and induces T cell suppression and Th2 immune polarization. We identify a GR-1(+)CD11b(+) population whose numbers dramatically increase and remain elevated in the spleen, lymph nodes, and bone marrow during polymicrobial sepsis. Phenotypicall...

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Main Authors: Delano, Matthew J., Scumpia, Philip O., Weinstein, Jason S., Coco, Dominique, Nagaraj, Srinivas, Kelly-Scumpia, Kindra M., O'Malley, Kerri A., Wynn, James L., Antonenko, Svetlana, Al-Quran, Samer Z., Swan, Ryan, Chung, Chun-Shiang, Atkinson, Mark A., Ramphal, Reuben, Gabrilovich, Dmitry I., Reeves, Wesley H., Ayala, Alfred, Phillips, Joseph, LaFace, Drake, Heyworth, Paul G., Clare-Salzler, Michael, Moldawer, Lyle L.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2007
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118626/
https://ncbi.nlm.nih.gov/pubmed/17548519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062602
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