Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18

Interleukin (IL)-18 is an important effector of innate and adaptive immunity, but its expression must also be tightly regulated because it can potentiate lethal systemic inflammation and death. Healthy and septic human neonates demonstrate elevated serum concentrations of IL-18 compared with adults....

詳細記述

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Wynn, James Lawrence, Wilson, Chris S., Hawiger, Jacek, Scumpia, Philip O., Marshall, Andrew F., Liu, Jin-Hua, Zharkikh, Irina, Wong, Hector R., Lahni, Patrick, Benjamin, John T., Plosa, Erin J., Weitkamp, Jörn-Hendrik, Sherwood, Edward R., Moldawer, Lyle L., Ungaro, Ricardo, Baker, Henry V., Lopez, M. Cecilia, McElroy, Steven J., Colliou, Natacha, Mohamadzadeh, Mansour, Moore, Daniel Jensen
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2016
主題:
PNAS Plus
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868456/
https://ncbi.nlm.nih.gov/pubmed/27114524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515793113
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