Durable antitumor responses to CD47 blockade require adaptive immune stimulation

Therapeutic antitumor antibodies treat cancer by mobilizing both innate and adaptive immunity. CD47 is an antiphagocytic ligand exploited by tumor cells to blunt antibody effector functions by transmitting an inhibitory signal through its receptor signal regulatory protein alpha (SIRPα). Interferenc...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Sockolosky, Jonathan T., Dougan, Michael, Ingram, Jessica R., Ho, Chia Chi M., Kauke, Monique J., Almo, Steven C., Ploegh, Hidde L., Garcia, K. Christopher
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868409/
https://ncbi.nlm.nih.gov/pubmed/27091975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604268113
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