Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade

Immunotherapy using checkpoint-blocking antibodies against PD-1 has produced impressive results in a wide range of cancers. However, the response remains heterogeneous among patients. We used noninvasive immuno-positron emission tomography (PET), using (89)Zr-labeled PEGylated single-domain antibody...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rashidian, Mohammad, LaFleur, Martin W., Verschoor, Vincent L., Dongre, Anushka, Zhang, Yun, Nguyen, Thao H., Kolifrath, Stephen, Aref, Amir R., Lau, Christie J., Paweletz, Cloud P., Bu, Xia, Freeman, Gordon J., Barrasa, M. Inmaculada, Weinberg, Robert A., Sharpe, Arlene H., Ploegh, Hidde L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708368/
https://ncbi.nlm.nih.gov/pubmed/31375632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905005116
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