Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters

BACKGROUND: CRAd-S-pk7 is a conditionally replicative oncolytic adenoviral vector that contains a survivin promoter and a pk7 fiber modification that confer tumor-specific transcriptional targeting and preferential replication in glioma while sparing the surrounding normal brain parenchyma. METHODS:...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Transl Med
Päätekijät: Kim, Julius Woongki, Auffinger, Brenda, Spencer, Drew A., Miska, Jason, Chang, Alan L., Kane, Joshua Robert, Young, Jacob S., Kanojia, Deepak, Qiao, Jian, Mann, Jill F., Zhang, Lingjiao, Wu, Meijing, Ahmed, Atique U., Aboody, Karen S., Strong, Theresa V., Hébert, Charles D., Lesniak, Maciej S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2016
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868110/
https://ncbi.nlm.nih.gov/pubmed/27184224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0895-8
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