Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters

BACKGROUND: CRAd-S-pk7 is a conditionally replicative oncolytic adenoviral vector that contains a survivin promoter and a pk7 fiber modification that confer tumor-specific transcriptional targeting and preferential replication in glioma while sparing the surrounding normal brain parenchyma. METHODS:...

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Pubblicato in:J Transl Med
Autori principali: Kim, Julius Woongki, Auffinger, Brenda, Spencer, Drew A., Miska, Jason, Chang, Alan L., Kane, Joshua Robert, Young, Jacob S., Kanojia, Deepak, Qiao, Jian, Mann, Jill F., Zhang, Lingjiao, Wu, Meijing, Ahmed, Atique U., Aboody, Karen S., Strong, Theresa V., Hébert, Charles D., Lesniak, Maciej S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868110/
https://ncbi.nlm.nih.gov/pubmed/27184224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0895-8
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