Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters

BACKGROUND: CRAd-S-pk7 is a conditionally replicative oncolytic adenoviral vector that contains a survivin promoter and a pk7 fiber modification that confer tumor-specific transcriptional targeting and preferential replication in glioma while sparing the surrounding normal brain parenchyma. METHODS:...

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Библиографические подробности
Опубликовано в: :J Transl Med
Главные авторы: Kim, Julius Woongki, Auffinger, Brenda, Spencer, Drew A., Miska, Jason, Chang, Alan L., Kane, Joshua Robert, Young, Jacob S., Kanojia, Deepak, Qiao, Jian, Mann, Jill F., Zhang, Lingjiao, Wu, Meijing, Ahmed, Atique U., Aboody, Karen S., Strong, Theresa V., Hébert, Charles D., Lesniak, Maciej S.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2016
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868110/
https://ncbi.nlm.nih.gov/pubmed/27184224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0895-8
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