Ozanimod (RPC1063) is a potent sphingosine‐1‐phosphate receptor‐1 (S1P(1)) and receptor‐5 (S1P(5)) agonist with autoimmune disease‐modifying activity

BACKGROUND AND PURPOSE: Sphingosine1‐phosphate (S1P) receptors mediate multiple events including lymphocyte trafficking, cardiac function, and endothelial barrier integrity. Stimulation of S1P(1) receptors sequesters lymphocyte subsets in peripheral lymphoid organs, preventing their trafficking to i...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Scott, F L, Clemons, B, Brooks, J, Brahmachary, E, Powell, R, Dedman, H, Desale, H G, Timony, G A, Martinborough, E, Rosen, H, Roberts, E, Boehm, M F, Peach, R J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2016
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867749/
https://ncbi.nlm.nih.gov/pubmed/26990079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13476
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