Ozanimod (RPC1063) is a potent sphingosine‐1‐phosphate receptor‐1 (S1P(1)) and receptor‐5 (S1P(5)) agonist with autoimmune disease‐modifying activity

BACKGROUND AND PURPOSE: Sphingosine1‐phosphate (S1P) receptors mediate multiple events including lymphocyte trafficking, cardiac function, and endothelial barrier integrity. Stimulation of S1P(1) receptors sequesters lymphocyte subsets in peripheral lymphoid organs, preventing their trafficking to i...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Main Authors: Scott, F L, Clemons, B, Brooks, J, Brahmachary, E, Powell, R, Dedman, H, Desale, H G, Timony, G A, Martinborough, E, Rosen, H, Roberts, E, Boehm, M F, Peach, R J
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867749/
https://ncbi.nlm.nih.gov/pubmed/26990079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13476
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