Apelin‐13 administration protects against ischaemia/reperfusion‐mediated apoptosis through the FoxO1 pathway in high‐fat diet‐induced obesity

BACKGROUND AND PURPOSE: Apelin‐13, an endogenous ligand for the apelin (APJ) receptor, behaves as a potent modulator of metabolic and cardiovascular disorders. Here, we examined the effects of apelin‐13 on myocardial injury in a mouse model combining ischaemia/reperfusion (I/R) and obesity and explo...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Boal, Frederic, Timotin, Andrei, Roumegoux, Jessica, Alfarano, Chiara, Calise, Denis, Anesia, Rodica, Parini, Angelo, Valet, Philippe, Tronchere, Helene, Kunduzova, Oksana
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867747/
https://ncbi.nlm.nih.gov/pubmed/27005319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13485
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