Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice

PIKfyve is an evolutionarily conserved lipid kinase that regulates pleiotropic cellular functions. Here, we identify PIKfyve as a key regulator of cardiometabolic status and mitochondrial integrity in chronic diet‐induced obesity. In vitro, we show that PIKfyve is critical for the control of mitocho...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Tronchere, Helene, Cinato, Mathieu, Timotin, Andrei, Guitou, Laurie, Villedieu, Camille, Thibault, Helene, Baetz, Delphine, Payrastre, Bernard, Valet, Philippe, Parini, Angelo, Kunduzova, Oksana, Boal, Frederic
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452048/
https://ncbi.nlm.nih.gov/pubmed/28396567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201607096
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