New use for an old drug: COX‐independent anti‐inflammatory effects of sulindac in models of cystic fibrosis

BACKGROUND AND PURPOSE: Pulmonary disease is the main cause of morbidity and mortality in cystic fibrosis (CF) patients due to exacerbated inflammation. To date, the only anti‐inflammatory drug available to CF patients is high‐dose ibuprofen, which can slow pulmonary disease progression, but whose c...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Rocca, Jérémy, Manin, Sylvie, Hulin, Anne, Aissat, Abdel, Verbecq‐Morlot, Wilfried, Prulière‐Escabasse, Virginie, Wohlhuter‐Haddad, Adeline, Epaud, Ralph, Fanen, Pascale, Tarze, Agathe
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867744/
https://ncbi.nlm.nih.gov/pubmed/26894321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13464
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