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Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells

Rapidly cycling LGR5+ intestinal stem cells (ISCs) located at the base of crypts are the primary driver of regeneration. Additionally, BMI1 expression is correlated with a slow cycling pool of ISCs located at +4 position. While previous reports have shown interconversion between these two population...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Srinivasan, Tara, Than, Elaine Bich, Bu, Pengcheng, Tung, Kuei-Ling, Chen, Kai-Yuan, Augenlicht, Leonard, Lipkin, Steven M., Shen, Xiling
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867651/
https://ncbi.nlm.nih.gov/pubmed/27181744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26069
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