Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

DDX3X is a DEAD-box RNA helicase that has been implicated in multiple aspects of RNA metabolism including translation initiation and the assembly of stress granules (SGs). Recent genomic studies have reported recurrent DDX3X mutations in numerous tumors including medulloblastoma (MB), but the physio...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Valentin-Vega, Yasmine A., Wang, Yong-Dong, Parker, Matthew, Patmore, Deanna M., Kanagaraj, Anderson, Moore, Jennifer, Rusch, Michael, Finkelstein, David, Ellison, David W., Gilbertson, Richard J., Zhang, Jinghui, Kim, Hong Joo, Taylor, J. Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867597/
https://ncbi.nlm.nih.gov/pubmed/27180681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25996
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