Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

DDX3X is a DEAD-box RNA helicase that has been implicated in multiple aspects of RNA metabolism including translation initiation and the assembly of stress granules (SGs). Recent genomic studies have reported recurrent DDX3X mutations in numerous tumors including medulloblastoma (MB), but the physio...

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Pubblicato in:Sci Rep
Autori principali: Valentin-Vega, Yasmine A., Wang, Yong-Dong, Parker, Matthew, Patmore, Deanna M., Kanagaraj, Anderson, Moore, Jennifer, Rusch, Michael, Finkelstein, David, Ellison, David W., Gilbertson, Richard J., Zhang, Jinghui, Kim, Hong Joo, Taylor, J. Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867597/
https://ncbi.nlm.nih.gov/pubmed/27180681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25996
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