Targeting multiple response regulators of Mycobacterium tuberculosis augments the host immune response to infection

The genome of M. tuberculosis (Mtb) encodes eleven paired two component systems (TCSs) consisting of a sensor kinase (SK) and a response regulator (RR). The SKs sense environmental signals triggering RR-dependent gene expression pathways that enable the bacterium to adapt in the host milieu. We demo...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Banerjee, Srijon Kaushik, Kumar, Manish, Alokam, Reshma, Sharma, Arun Kumar, Chatterjee, Ayan, Kumar, Ranjeet, Sahu, Sanjaya Kumar, Jana, Kuladip, Singh, Ramandeep, Yogeeswari, Perumal, Sriram, Dharmarajan, Basu, Joyoti, Kundu, Manikuntala
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867592/
https://ncbi.nlm.nih.gov/pubmed/27181265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25851
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