Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes

[Image: see text] In our efforts to develop second generation DPP-4 inhibitors, we endeavored to identify distinct structures with long-acting (once weekly) potential. Taking advantage of X-ray cocrystal structures of sitagliptin and other DPP-4 inhibitors, such as alogliptin and linagliptin bound t...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :ACS Med Chem Lett
Главные авторы: Wu, Wen-Lian, Hao, Jinsong, Domalski, Martin, Burnett, Duane A., Pissarnitski, Dmitri, Zhao, Zhiqiang, Stamford, Andrew, Scapin, Giovanna, Gao, Ying-Duo, Soriano, Aileen, Kelly, Terri M., Yao, Zuliang, Powles, Mary Ann, Chen, Shiying, Mei, Hong, Hwa, Joyce
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2016
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867478/
https://ncbi.nlm.nih.gov/pubmed/27190600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00027
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы