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Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction

[Image: see text] GPR4, a pH-sensing G protein-coupled receptor, is highly expressed in endothelial cells and may be activated in myocardial infarction due the decreased tissue pH. We are interested in GPR4 antagonists as potential effective pharmacologic tools and/or drug leads for the treatment of...

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Publicat a:ACS Med Chem Lett
Autors principals: Fukuda, Hayato, Ito, Saki, Watari, Kenji, Mogi, Chihiro, Arisawa, Mitsuhiro, Okajima, Fumikazu, Kurose, Hitoshi, Shuto, Satoshi
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2016
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867472/
https://ncbi.nlm.nih.gov/pubmed/27190599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00014
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