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Phenotypic extremes in rare variant study designs
Currently, next-generation sequencing studies aim to identify rare and low-frequency variation that may contribute to disease. For a given effect size, as the allele frequency decreases, the power to detect genes or variants of interest also decreases. Although many methods have been proposed for th...
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| 出版年: | Eur J Hum Genet |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4867440/ https://ncbi.nlm.nih.gov/pubmed/26350511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2015.197 |
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