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Cardiac angiotensin-(1–12) expression and systemic hypertension in rats expressing the human angiotensinogen gene
Angiotensin-(1–12) [ANG-(1–12)] is processed into ANG II by chymase in rodent and human heart tissue. Differences in the amino acid sequence of rat and human ANG-(1–12) render the human angiotensinogen (hAGT) protein refractory to cleavage by renin. We used transgenic rats harboring the hAGT gene [T...
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| Publicado no: | Am J Physiol Heart Circ Physiol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4867338/ https://ncbi.nlm.nih.gov/pubmed/26873967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00833.2015 |
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