Withaferin A inhibits in vivo growth of breast cancer cells accelerated by Notch2 knockdown

PURPOSE: The present study offers novel insights into the molecular circuitry of accelerated in vivo tumor growth by Notch2 knockdown in triple-negative breast cancer (TNBC) cells. Therapeutic vulnerability of Notch2-altered growth to a small molecule (withaferin A; WA) is also demonstrated. METHODS...

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Publicado no:Breast Cancer Res Treat
Main Authors: Kim, Su-Hyeong, Hahm, Eun-Ryeong, Arlotti, Julie A., Samanta, Suman K., Moura, Michelle B., Thorne, Stephen H., Shuai, Yongli, Anderson, Carolyn J., White, Alexander G., Lokshin, Anna, Lee, Joomin, Singh, Shivendra V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867258/
https://ncbi.nlm.nih.gov/pubmed/27097807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-016-3795-y
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