Chemotherapy-induced Inflammatory Gene Signature and Pro-tumorigenic Phenotype in Pancreatic CAFs via Stress-associated MAPK

Pancreatic ductal adenocarcinoma (PDAC) has a characteristically dense stroma comprised predominantly of cancer associated fibroblasts (CAFs). CAFs promote tumor growth, metastasis and treatment resistance. This study aimed to investigate the molecular changes and functional consequences associated...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Toste, Paul A., Nguyen, Andrew H., Kadera, Brian E., Duong, Mindy, Wu, Nanping, Gawlas, Irmina, Tran, Linh M., Bikhchandani, Mihir, Li, Luyi, Patel, Sanjeet G., Dawson, David W., Donahue, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867256/
https://ncbi.nlm.nih.gov/pubmed/26979711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0348
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