The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing".
The amiloride-sensitive Na+/H+ exchanger (NHE1 human isoform) is activated in response to diverse mitogenic and oncogenic signals presumably through phosphorylation. To get insight into the activating mechanism, a set of deletion mutants within the C-terminal cytoplasmic domain of NHE1 has been gene...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1992
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48670/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1372444/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.6.2424 |
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