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Direct Catalytic Asymmetric Mannich Reactions for the Construction of Quaternary Carbon Stereocenters
Herein, we report a Zn-ProPhenol catalyzed Mannich reaction using α-branched ketones as nucleophilic partners for the direct enantio- and diastereoselective construction of quaternary carbon stereocenters. The reaction can be run on a gram-scale with a low catalyst loading without impacting its effi...
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| Published in: | J Am Chem Soc |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4866641/ https://ncbi.nlm.nih.gov/pubmed/26952276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b01187 |
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