Disruption of relative reward value by reversible disconnection of orbitofrontal and rhinal cortex using DREADDs in rhesus monkeys

To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using the hM4Di-DREADD (Designer Receptor Exclusively Activated by Designer Drug). Repeated inactivation reduced sensitivity to differenc...

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Veröffentlicht in:Nat Neurosci
Hauptverfasser: Eldridge, Mark A G, Lerchner, Walter, Saunders, Richard C, Kaneko, Hiroyuki, Krausz, Kristopher W, Gonzalez, Frank J, Ji, Bin, Higuchi, Makoto, Minamimoto, Takafumi, Richmond, Barry J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866611/
https://ncbi.nlm.nih.gov/pubmed/26656645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4192
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