Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits

Lassa fever is a severe multisystem disease that often has haemorrhagic manifestations. The epitopes of the Lassa virus (LASV) surface glycoproteins recognized by naturally infected human hosts have not been identified or characterized. Here we have cloned 113 human monoclonal antibodies (mAbs) spec...

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Vydáno v:Nat Commun
Hlavní autoři: Robinson, James E., Hastie, Kathryn M., Cross, Robert W., Yenni, Rachael E., Elliott, Deborah H., Rouelle, Julie A., Kannadka, Chandrika B., Smira, Ashley A., Garry, Courtney E., Bradley, Benjamin T., Yu, Haini, Shaffer, Jeffrey G., Boisen, Matt L., Hartnett, Jessica N., Zandonatti, Michelle A., Rowland, Megan M., Heinrich, Megan L., Martínez-Sobrido, Luis, Cheng, Benson, de la Torre, Juan C., Andersen, Kristian G., Goba, Augustine, Momoh, Mambu, Fullah, Mohamed, Gbakie, Michael, Kanneh, Lansana, Koroma, Veronica J., Fonnie, Richard, Jalloh, Simbirie C., Kargbo, Brima, Vandi, Mohamed A., Gbetuwa, Momoh, Ikponmwosa, Odia, Asogun, Danny A., Okokhere, Peter O., Follarin, Onikepe A., Schieffelin, John S., Pitts, Kelly R., Geisbert, Joan B., Kulakoski, Peter C., Wilson, Russell B., Happi, Christian T., Sabeti, Pardis C., Gevao, Sahr M., Khan, S. Humarr, Grant, Donald S., Geisbert, Thomas W., Saphire, Erica Ollmann, Branco, Luis M., Garry, Robert F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866400/
https://ncbi.nlm.nih.gov/pubmed/27161536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11544
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