Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits

Lassa fever is a severe multisystem disease that often has haemorrhagic manifestations. The epitopes of the Lassa virus (LASV) surface glycoproteins recognized by naturally infected human hosts have not been identified or characterized. Here we have cloned 113 human monoclonal antibodies (mAbs) spec...

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Publicado no:Nat Commun
Main Authors: Robinson, James E., Hastie, Kathryn M., Cross, Robert W., Yenni, Rachael E., Elliott, Deborah H., Rouelle, Julie A., Kannadka, Chandrika B., Smira, Ashley A., Garry, Courtney E., Bradley, Benjamin T., Yu, Haini, Shaffer, Jeffrey G., Boisen, Matt L., Hartnett, Jessica N., Zandonatti, Michelle A., Rowland, Megan M., Heinrich, Megan L., Martínez-Sobrido, Luis, Cheng, Benson, de la Torre, Juan C., Andersen, Kristian G., Goba, Augustine, Momoh, Mambu, Fullah, Mohamed, Gbakie, Michael, Kanneh, Lansana, Koroma, Veronica J., Fonnie, Richard, Jalloh, Simbirie C., Kargbo, Brima, Vandi, Mohamed A., Gbetuwa, Momoh, Ikponmwosa, Odia, Asogun, Danny A., Okokhere, Peter O., Follarin, Onikepe A., Schieffelin, John S., Pitts, Kelly R., Geisbert, Joan B., Kulakoski, Peter C., Wilson, Russell B., Happi, Christian T., Sabeti, Pardis C., Gevao, Sahr M., Khan, S. Humarr, Grant, Donald S., Geisbert, Thomas W., Saphire, Erica Ollmann, Branco, Luis M., Garry, Robert F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866400/
https://ncbi.nlm.nih.gov/pubmed/27161536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11544
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