Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation

BACKGROUND: Differentiation of lymphocytes is frequently accompanied by cell cycle changes, interplay that is of central importance for immunity but is still incompletely understood. Here, we interrogate and quantitatively model how proliferation is linked to differentiation in CD4+ T cells. RESULTS...

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Zapisane w:
Opis bibliograficzny
Wydane w:Genome Biol
Główni autorzy: Proserpio, Valentina, Piccolo, Andrea, Haim-Vilmovsky, Liora, Kar, Gozde, Lönnberg, Tapio, Svensson, Valentine, Pramanik, Jhuma, Natarajan, Kedar Nath, Zhai, Weichao, Zhang, Xiuwei, Donati, Giacomo, Kayikci, Melis, Kotar, Jurij, McKenzie, Andrew N. J., Montandon, Ruddy, Billker, Oliver, Woodhouse, Steven, Cicuta, Pietro, Nicodemi, Mario, Teichmann, Sarah A.
Format: Artigo
Język:Inglês
Wydane: BioMed Central 2016
Hasła przedmiotowe:
Research
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866375/
https://ncbi.nlm.nih.gov/pubmed/27176874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0957-5
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