Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation

BACKGROUND: Differentiation of lymphocytes is frequently accompanied by cell cycle changes, interplay that is of central importance for immunity but is still incompletely understood. Here, we interrogate and quantitatively model how proliferation is linked to differentiation in CD4+ T cells. RESULTS...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Proserpio, Valentina, Piccolo, Andrea, Haim-Vilmovsky, Liora, Kar, Gozde, Lönnberg, Tapio, Svensson, Valentine, Pramanik, Jhuma, Natarajan, Kedar Nath, Zhai, Weichao, Zhang, Xiuwei, Donati, Giacomo, Kayikci, Melis, Kotar, Jurij, McKenzie, Andrew N. J., Montandon, Ruddy, Billker, Oliver, Woodhouse, Steven, Cicuta, Pietro, Nicodemi, Mario, Teichmann, Sarah A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866375/
https://ncbi.nlm.nih.gov/pubmed/27176874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0957-5
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