Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation

BACKGROUND: Differentiation of lymphocytes is frequently accompanied by cell cycle changes, interplay that is of central importance for immunity but is still incompletely understood. Here, we interrogate and quantitatively model how proliferation is linked to differentiation in CD4+ T cells. RESULTS...

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Publicado en:Genome Biol
Autores principales: Proserpio, Valentina, Piccolo, Andrea, Haim-Vilmovsky, Liora, Kar, Gozde, Lönnberg, Tapio, Svensson, Valentine, Pramanik, Jhuma, Natarajan, Kedar Nath, Zhai, Weichao, Zhang, Xiuwei, Donati, Giacomo, Kayikci, Melis, Kotar, Jurij, McKenzie, Andrew N. J., Montandon, Ruddy, Billker, Oliver, Woodhouse, Steven, Cicuta, Pietro, Nicodemi, Mario, Teichmann, Sarah A.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866375/
https://ncbi.nlm.nih.gov/pubmed/27176874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0957-5
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