Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation

BACKGROUND: Differentiation of lymphocytes is frequently accompanied by cell cycle changes, interplay that is of central importance for immunity but is still incompletely understood. Here, we interrogate and quantitatively model how proliferation is linked to differentiation in CD4+ T cells. RESULTS...

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Détails bibliographiques
Publié dans:Genome Biol
Auteurs principaux: Proserpio, Valentina, Piccolo, Andrea, Haim-Vilmovsky, Liora, Kar, Gozde, Lönnberg, Tapio, Svensson, Valentine, Pramanik, Jhuma, Natarajan, Kedar Nath, Zhai, Weichao, Zhang, Xiuwei, Donati, Giacomo, Kayikci, Melis, Kotar, Jurij, McKenzie, Andrew N. J., Montandon, Ruddy, Billker, Oliver, Woodhouse, Steven, Cicuta, Pietro, Nicodemi, Mario, Teichmann, Sarah A.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866375/
https://ncbi.nlm.nih.gov/pubmed/27176874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0957-5
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