Increased Th17 cells and IL-17A exist in patients with B cell acute lymphoblastic leukemia and promote proliferation and resistance to daunorubicin through activation of Akt signaling

BACKGROUND: Immune regulation is crucial for the pathogenesis of B-cell acute lymphoblastic leukemia (B-ALL). It has been reported that Th17 cells as a newly identified subset of CD4(+) T cells are involved in the pathogenesis of several hematological disorders. However, the role of Th17 cells in th...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Bi, Laixi, Wu, Junqing, Ye, Aifang, Wu, Jianbo, Yu, Kang, Zhang, Shenghui, Han, Yixiang
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866013/
https://ncbi.nlm.nih.gov/pubmed/27176825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0894-9
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