Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

BACKGROUND: Despite the clear physical association between activated astrocytes and amyloid-β (Aβ) plaques, the importance of astrocytes and their therapeutic potential in Alzheimer’s disease remain elusive. Soluble Aβ aggregates, such as protofibrils, have been suggested to be responsible for the w...

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Publicado en:Mol Neurodegener
Autores principales: Söllvander, Sofia, Nikitidou, Elisabeth, Brolin, Robin, Söderberg, Linda, Sehlin, Dag, Lannfelt, Lars, Erlandsson, Anna
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865996/
https://ncbi.nlm.nih.gov/pubmed/27176225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0098-z
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