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Hypoxia-activated prodrugs: paths forward in the era of personalised medicine
Tumour hypoxia has been pursued as a cancer drug target for over 30 years, most notably using bioreductive (hypoxia-activated) prodrugs that target antineoplastic agents to low-oxygen tumour compartments. Despite compelling evidence linking hypoxia with treatment resistance and adverse prognosis, a...
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| Udgivet i: | Br J Cancer |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4865974/ https://ncbi.nlm.nih.gov/pubmed/27070712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.79 |
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