Inhibition of PRL-2·CNNM3 Protein Complex Formation Decreases Breast Cancer Proliferation and Tumor Growth

The oncogenic phosphatase of regenerating liver 2 (PRL-2) has been shown to regulate intracellular magnesium levels by forming a complex through an extended amino acid loop present in the Bateman module of the CNNM3 magnesium transporter. Here we identified highly conserved residues located on this...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kostantin, Elie, Hardy, Serge, Valinsky, William C., Kompatscher, Andreas, de Baaij, Jeroen H. F., Zolotarov, Yevgen, Landry, Melissa, Uetani, Noriko, Martínez-Cruz, Luis Alfonso, Hoenderop, Joost G. J., Shrier, Alvin, Tremblay, Michel L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865918/
https://ncbi.nlm.nih.gov/pubmed/26969161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.705863
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