Activation of the cAMP-PKA pathway Antagonizes Metformin Suppression of Hepatic Glucose Production

Metformin is the most commonly prescribed oral anti-diabetic agent worldwide. Surprisingly, about 35% of diabetic patients either lack or have a delayed response to metformin treatment, and many patients become less responsive to metformin over time. It remains unknown how metformin resistance or in...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: He, Ling, Chang, Evan, Peng, Jinghua, An, Hongying, McMillin, Sara M., Radovick, Sally, Stratakis, Constantine A., Wondisford, Fredric E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865906/
https://ncbi.nlm.nih.gov/pubmed/27002150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.719666
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