Metformin and Insulin Suppress Hepatic Gluconeogenesis by Inhibiting cAMP Signaling Through Phosphorylation of CREB Binding Protein (CBP)

Insulin resistance and elevated glucagon levels result in non-suppressible hepatic glucose production and hyperglycemia in patients with type 2 diabetes. The CREB co-activator complex controls transcription of hepatic gluconeogenic enzyme genes. Here we show that both the antidiabetic agent metformi...

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Detalhes bibliográficos
Main Authors: He, Ling, Sabet, Amin, Djedjos, Stephen, Miller, Ryan, Sun, Xiaojian, Hussain, Mehboob A., Radovick, Sally, Wondisford, Fredric E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775562/
https://ncbi.nlm.nih.gov/pubmed/19450513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.03.016
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