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The conserved core enzymatic activities and the distinct dynamics of polyomavirus large T antigens

Several human polyomaviruses including JCV, BKV and TSV are associated with diseases, particularly in immunosuppressed patients. While the large T antigen (LT) encoded by the monkey polyomavirus SV40 is well studied, and possesses intrinsic ATPase and DNA helicase activities, the LTs of the human po...

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Bibliographic Details
Published in:Arch Biochem Biophys
Main Authors: An, Ping, Brodsky, Jeffrey L., Pipas, James M.
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865250/
https://ncbi.nlm.nih.gov/pubmed/25752954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2015.02.033
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